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KMID : 0358419960390091711
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Korean Journal of Obstetrics and Gynecology
1996 Volume.39 No. 9 p.1711 ~ p.1719
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Effect of Substance P and Calcitonin Gene-Related Peptide on Pain Receptor in Cat Uterus
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이상희
이서은/윤영욱/한희철/홍승길/나중열
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Abstract
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To study the effects of substance P and calcitonin gene-related peptide(CGRP) on the pain receptors in cat uterus, electrophysiological recordings of uterine afferents from hypogastric nerve were conducted.
Extracellular recordings were made from the hypogastric nerve filaments in a-chloralose anesthetized cats. Intra-arterial injection of substance P and CGRP was achieved through the micro-polyethylene tube installed at one of the branch of uterine
artery.
Eleven A δand twelve C fibers were recorded. The responses of these fibers to substance P or CGRP were not definite at a glance. Unlike the uterine nociceptor responses to algesic substances, substance P or CGRP produced little changes in
impluse
discharge rates. But these changes were significantly different. A δfibers were effected by CGRP but not by substance P. C fibers were stimulated by substance P but not by CGRP. The response duration of C fibers to substance P were brief(1~2 min
after
injection) but effects of CGRP on A δ fibers were prolonged(>15 min after injection).
These results indicate that substance P and CGRP may have neuromodulatory functions in peripheral tissue. But the mechanisms of these peptides may be very different and their targets also can be distinguished from each other.
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KEYWORD
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